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    王敏盈 教授

    Wang, Min-Ying

    王敏盈 教授

    Email: mywang@dragon.nchu.edu.tw

    地址:中興大學食品暨生物科技大樓7F

    Office phone:22840328 ext.761 

    Lab phone:22840328 ext.763

    研究專長

    蛋白質生產與純化、生物化學工程

    學經歷

    • B.S. 國立台灣大學化工系, 1986
    • M.S. 國立台灣大學生化所, 1990
    • Ph.D. University of Maryland at College Park, l994
    • Post-Doctoral National Institutes of Health, l994-1995
    • 副教授 國立中興大學生物科技所, 1995-2003
    • 教授 國立中興大學生物科技所, 2003-present

    主要教授課程 (含大學部及研究所)

    • 生物技術特論
    • 生物化學 
    • 生化工程概論
    • 高等生化工程

    研究興趣

           本實驗室的目標是利用昆蟲細胞/ 桿狀病毒表達系統（Insect cell culture/ baculovirus expression system）來生產似病毒粒子 (Virus-like particles, 簡稱 VLPs) 當作防治雞傳染性華氏囊病的疫苗，雞傳染性華氏囊病是由傳染性華氏囊病毒 (Infectious Bursal Disease Virus, 簡稱 IBDV) 所引起。

          之所以利用似病毒粒子而不用單一次單元蛋白的原因是似病毒粒子通常才能保有真正病毒原本之空間立體結構且誘發高titer 的中和抗體，是比較好的疫苗；而且這些似病毒粒子本身又不帶有 DNA 或 RNA 等遺傳性物質，就此點而言，發展似病毒粒子當作疫苗，又比用馴化活毒疫苗或死毒疫苗來得安全。

          以似病毒粒子當作疫苗是未來疫苗發展的一重要方向，我們將有系統兼定量性研究發展似病毒粒子之生產，及如何形成、如何簡易其純化步驟。

          IBDV 是影響全世界養雞產業經濟效益的主要病源體，所以它是一個非常好的模型系統，以後我們會朝其他疫苗發展(如C型肝炎疫苗)，以增強台灣疫苗開發及生產能力。 
     
     
     

    期刊論文

    1. Meng-Chuan Wu, John Jaime Perez Coca, Gary Ro-Lin Chang, Shing-Yi Suen, Chia-Feng Lin, Hong-Nong Chou, Su-Yuan Lai and Min-Ying Wang*, 2012. "Chemical Modification of a Diatom’s Frustules for Protein and Viral Nanopartcile Adsorption" submitted to Process Biochemistry.
       
    2. Tsung-Hsien Chen, Ten-Hong Chen, Chung-Chi Hu, Jia-Teh Liao, Chin-Wei Lee, Jiunn-Wang Liao, Maw-Yeong Lin, Hung-Jen Liue, Min-Ying Wang, Na-Sheng Lin,f, Yau-Heiu Hsu, 2012 “Induction of protective immunity in chickens immunized with plant-made chimeric Bamboo mosaic virus particles expressing very virulent Infectious bursal disease virus antigen” Virus Research (accepted)
       
    3. Gary Ro-Lin Chang＃, Min-Ying Wang＃, Jiahn-Haur Liao, Yu-Ping Hsiao, Che-Wei Lee and Su-Yuan Lai*, 2011. “E. coli-derived VP4 Tubules of Infectious Bursal Disease Virus Have an Endopeptidase Activity” submitted to Process Biochemistry. 
       
    4. Gary Ro-Lin Chang, Su-Yuan Lai, Poa-Chun Chang and Min-Ying Wang*, 2011. " Production of Immunogenic One-Component Avian H7-Subtype Influenza Virus-like Particles " Process Biochemistry 46:1292-1298 (SCI, Impact factor (2010): 2.648, Engineering, chemical, 17/135) 計畫編號: Grant No. NSC95-2313-B-005-036-MY2. 
       
    5. Meng-Shiou Lee, Yi-Chiu Lin, Guan-Hua Lai, Su-Yaun Lai, Hsi-Jien Chen, Min-Ying Wang*, 2011. “One-step reverse transcription loop-mediated isothermal amplification for detection of infectious bursal disease virus.” Canadian Journal of Veterinary Research 75(2): 122-127 (SCI, Impact factor (2010):1.294, VETERINARY SCIENCES, 40/145) 計畫編號: Grant No. NSC97-2622-E-005-007-CC3, NSC 97-2313-B-005-009-MY3.
       
    6. Jin-Yi Ho, Long-Huw Lee, Yu-Chiang Lin, Yu-Jui Tai, Cheng-Kai Chang, Yu-mei Chou, Su-Yuan Lai and Min-Ying Wang*, 2010. "Vaccine Development through Terminal Deletions of an Infectious Bursal Disease Virus Protein 2 Precursor Variant" Process Biochemistry 45:786-793 (SCI, Impact factor (2010): 2.648, Engineering, chemical, 17/135) 計畫編號: Grant No. NSC90-2317-B-005-001 and NSC92-2313-B-005-119. 
       
    7. Shwu-Jinng Wang, Wei-Feng Chang, Min-Ying Wang, Kuang-Pin Hsiung, Yung-Chuan Liu*, 2008. “Development of a disperse dye immunochromatographic test for the detection of antibodies against infectious bursal disease virus.” Veterinary Immunology and Immunopathology (125:284-290). (SCI, Impact factor (2010):2.176,VETERINARY SCIENCES, 13/141)   
       
    8. Min-Ying Wang, Hui-Ling Hu, Shing-Yi Suen, Fang-Yi Chiu, Jui-Hung Shien, and Su-Yuan Lai*, 2008. “Development of an Enzyme-linked Immunosorbent Assay for Detecting Infectious Bursal Disease Virus (IBDV) Infection Based on the VP3 Structural Protein.” Veterinary Microbiology 131:229-236. (SCI, Impact factor (2010): 3.256,VETERINARY SCIENCES, 3/145) 
       
    9. Doong, Shyue-Ru; Chen, Yi-Huei; Lai, Su-Yuan; Lee, Cheng-Chung; Lin, Yu-Chiang; Min-Ying Wang*, 2007. "A Strong and Heterogeneous Adsorption of Infectious Bursal Disease VP2 Subviral Particle with Immobilized Metal Ions Depends on Two Surface Histidine Residues" Analytical Chemistry. 79:7654-7661. (SCI, Impact factor (2010): 5.874,CHEMISTRY, ANALYTICAL, 3/73)
       
    10. Ta-Wei Lin, Chi-Wen Lo, Su-Yuan Lai, Ruey-Jane Fan, Chao-Jung Lo, Yu-mei Chou, Rekha Thiruvengadam, Andrew H.-J. Wang and Min-Ying Wang*, 2007. “Chicken Heat Shock Protein 90 Is a Component of the Putative Cellular Receptor Complex of Infectious Bursal Disease Virus” Journal of Virology. 81:8730-8741. (SCI, Impact factor (2010):5.189,VIROLOGY, 5/33) 計畫編號: NSC 93-2313-B-005-070 to M.-Y.W. and NSC 92-2751-B-001-017-Y to A.H.-J.W. and M.-Y.W.) 
       
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