Vikram Virdi, Jorge Palaci, Bram Laukens, Stefan Ryckaert, Eric Cox, Erik Vanderbeke, Ann Depicker and Nico Callewaert
Nature biotechnology 37, pages 527–530
Published: 2019
Oral antibodies that interfere with gastrointestinal targets and can be manufactured at scale are needed. Here we show that a single-gene-encoded monomeric immunoglobulin A (IgA)-like antibody, composed of camelid variable single domain antibodies (VHH) fused to IgA Fc (mVHH-IgA), prevents infection by enterotoxigenic Escherichia coli (F4-ETEC) in piglets. The mVHH-IgA can be produced in soybean seeds or secreted from the yeast Pichia pastoris, freeze- or spraydried and orally delivered within food.
指導教授：徐堯煇、王敏盈 教授
報告順序：20191101-1
組員：生技碩二 蔡宗原 、生技碩一 余佳樺 、生技碩一 陳國凱
