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基本資料表

孟孟孝←
(04)22840328 ext. 636, 637, 638
孟孟孝←

教師

專任師資
教授
•上學期:
生物技術
酵素學
酵素工程

•下學期:
生物技術特論
生物技術
酵素學
酵素工程

•暑期:
分子生物學技術(研究所)
蛋白質生化學,酵素工程
學年度論文名稱
111Liu, Y.-Y., Lin, I.-C., Chen, P.-C., Lee, C.-C., Meng, M*,(2022)Crystal structure of a Burkholderia peptidase and modification of the substrate-binding site for enhanced hydrolytic activity toward gluten-derived pro-immunogenic peptides.,Int. J. Biol. Macromol 222, 2258-2269.
111Diyapoglu, A., Chang, T.-H., Chang, P.-F. L., Yen, J.-H., Chiang, H.-I., Meng, M*,(2022) Fumigant activity of bacterial volatile organic compounds against the nematodes Caenorhabditis elegans and Meloidogyne incognita. ,Molecules 27, 4714.
111Diyapoglu, A., Oner, M., Meng, M*.,(2022) Application potential of bacterial volatile organic compounds in the control of root-knot nematodes. ,Molecules 27, 4355.
1114. Wu, S.-M., Jan, Y.-J., Tsai, S.-C., Pan, H.-C., Shen, C.-C., Yang, C.-N., Lee, S.-H., Liu, S.-H.,,(2022) Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer. ,Cell Biol. Toxicol. 1-24.
110Lin, Y.-T., Lee, C.-C., Leu, W.-M., Wu, J.-J., Huang, Y.-C., Meng, M.*, (2021) Fungicidal activity of volatile organic compounds emitted by Burkholderia gladioli strain BBB-01. ,Molecules, 26, 745.,(SCI)
110Liu, Y.-Y., Lee, C.-C., Hsu, J.-H., Leu,W.-M. Meng, M.*, (2021) Efficient hydrolysis of gluten-derived celiac disease-triggering immunogenic peptides by a bacterial serine protease from Burkholderia gladioli. ,Biomolecules 11, 451. ,(SCI)
110Hsiao, T.-H., Chen, Y.-L., Meng, M., Chuang, M.-R., Horinouchi, M., Hayashi, T., Wang, P.-H*., Chian, (2021) Mechanistic and phylogenetic insights into actinobacteria-mediated oestrogen biodegradation in urban estuarine sediments. Microb. ,Biotechnol. 14, 1212-1227.
110Hsiao, T.-H., Lee, T.-H., Chuang, M.-R., Wang, P.-H., Meng, M., Horinouchi, M., Hayashi, T., Chen, Y, (2021) Identification of essential β-oxidation genes and corresponding metabolites for oestrogen degradation by actinobacteria. ,Microb Biotechnol. Sep 15. doi: 10.1111/1751-7915.13921.,(SCI)
110Huang, Y.-W., Sun, C.-I., Hu, C.-C., Tsai, C.-H., Meng, M., Lin, N.-S., Hsu, Y.-H., (2021). NbPsbO1 Interacts Specifically with the Bamboo Mosaic Virus (BaMV) Subgenomic RNA (sgRNA) Promoter and Is Required for Efficient BaMV sgRNA Transcription. ,J. Virol. 95(20), e0083121.,(SCI)
110Shen, C., Tung, C., Chao, C., Jou, Y., Huang, S., Meng, M., Chang, D., Chen, P., (2021) The differential presence of human polyomaviruses, JCPyV and BKPyV, in prostate cancer and benign prostate hypertrophy tissues.,BMC Cancer. 21(1):1141.,(SCI)
108Lee, C.C., Wang, J.W., Leu, W.M., Huang, Y.T., Huang, Y.W., Hsu, Y.H., Meng, M*., (2019) Proliferating cell nuclear antigen suppresses RNA replication of Bamboo mosaic virus through an interaction with the viral genome. , J. Virol. 93:e00961-19. ,(SCI)
108Cheepudom, J., Lin, T.-L., Cheng-Cheng Lee, C.-C., Meng, M*., (2019) Characterization of a novel Thermobifida fusca bacteriophage P318., Viruses MDPI 11:1042.,(SCI)
108Ahmed, N., Meng, M*., (2019) Detection of gluten-rich cereals in processed food with enhanced sensitivity by targeting mitochondrial DNA using PCR., Food Anal. Method 12:811–825. ,(SCI)
107Lee, C.-C., Wu, Y.-J., Hsueh, C.-H., Huang, Y.-T., Hsu, Y.-H., Meng. M*. (2018) Mitogen-activated protein kinase phosphatase 1 reduces the replication efficiency of Bamboo mosaic virus in Nicotiana benthamiana., Mol Plant Pathol. 19:2319-2332.,(SCI)
107Lee, C.-C., Lin, M.-L.*, Meng, M.*, Chen, S.-S.* (2018) Galangin induces p53-independent S-phase arrest and apoptosis in human nasopharyngeal carcinoma cells through inhibiting PI3K-AKT signaling pathway., Anticancer Res. 38:1377-1389.,(SCI)
106Meng, M*., Lee, C.-C. (2017) Function and structural organization of the replication protein of Bamboo mosaic virus., Front. Microbiol. 8:522. ,(SCI)
105Chen, C.-Y. , Lee, C.-C. , Chen, H.-S., Yang, C.-H., Wang, S.-P., Wu, J.-H., Meng, M.* (2016) Modification of lignin in sugarcane bagasse by a monocopper hydrogen peroxide-generating oxidase from Thermobifida fusca., Proc. Biochem. 51:1486-1495.,(SCI)
105Lee, C.-C., Lin, T.-L., Lin, J.-W., Han, Y.-T., Huang, Y.-T., Hsu, Y.-H., Meng, M.* (2016) Promotion of Bamboo mosaic virus accumulation in Nicotiana benthamiana by 5’→3’ exonuclease NbXRN4., Front. Microbiol. 6:1508. ,(SCI)
104Yang, T.-H., Hsu, P.-Y., Meng, M., Su, C.-C.* (2015) Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis., Arthritis Res. Ther. 17: 364. ,(SCI)
104Yang, T.-H., Yuan, T.-H., Hwang, Y.-H., Lian, I.-B., Meng, M., Su, C.-C.* (2015) Increased inflammation in rheumatoid arthritis patients living where farm soils contain high levels of copper., J. Formos. Med. Assoc. 115:991-996,(SCI)
104Cheepudom, J., Lee, C.-C., Cai, B., Meng, M.* (2015) Isolation, characterization and complete genome analysis of P1312, a thermostable bacteriophage that infects Thermobifida fusca., Front. Microbiol. 6:959. ,(SCI)
104Lin, H.-Y., Liu, J.-H., Cheng, K.-L., Lin, J.-Y., Liu, N.-R., Meng, M.* (2015) A Novel Binding of GTP Stabilizes the Structure and Modulates the Activities of Human Phosphoglucose Isomerase/Autocrine Motility Factor., Biochemistry and Biophysics Report, 2:14-22. ,(SCI)
103Yeh, C.-H., Kuo, Y.-S., Chang, C.-M., Liu, W.-H., Sheu, M.-L., Meng, M*. (2014) Deletion of the gene encoding the reductase component of 3-ketosteroid 9-hydroxylase in Rhodococcus equi USA-18 disrupts sterol catabolism, leading to the accumulation of 3-oxo-23,24-bisnorchola-1,4-diene-22-oicacid and 1,4-androstadiene-3,17-dione., Microb. Cell Fact. 13:130,(SCI)
103Hung, C.-J., Hu, C.-C., Lin, N.-S., Lee, Y.-C., Meng, M., Tsai, C.-H., Hsu, Y.-H.* (2014) Two key arginine residues in the coat protein of Bamboo mosaic virus differentially affect the accumulation of viral genomic and subgenomic RNAs., Molecular Plant Pathology, 15:196-210.,(SCI)
103Hung, C.-J., Huang, Y.-W., Liou, M.-R., Lee, Y.-C., Lin, N.-S., Meng, M., Tsai, C.-H., Hu, C.-C.*, Hsu, Y.-H.* (2014) Phosphorylation of coat protein by protein kinase CK2 regulates cell-to-cell movement of Bamboo mosaic virus through modulating RNA binding., Mol. Plant Microbe. In. 27:1211-1225.,(SCI)
102Chen, C.-Y., Huang, Y.-C., Wei, C.-M., Meng, M., Liu, W.-H., Yang, C.-H*. (2013) Properties of the newly isolated extracellular thermo-alkali-stable laccase from thermophilic actinomycetes, Thermobifida fusca and its application in dye intermediates oxidation., AMB Express. 3:49,(SCI)
102Chou, Y.-L., Hung, Y.-J., Tseng, Y.-H., Hsu, H.-T., Yang, J.-Y.i, Wung, C.-H., Lin, N.-S., Meng, M.,, Chang, B.-Y.* (2013) The stable association of virion with the triple-gene block protein 3-based complex of Bamboo mosaic virus., PLoS Pathog. June;9(6): e1003405,(SCI)
102Chen, C.-Y., Hsieh, Z.-S., Cheepudom, J., Yang, C.-H., Meng, M.* (2013) A 24.7-kDa copper-containing oxidase, secreted by Thermobifida fusca, significantly increasing the xylanase/cellulase-catalyzed hydrolysis of sugarcane bagasse., Appl. Microbiol. Biotechnol. 97:8977-8986,(SCI)
102Liu, K.-C., Ho, H.-C., Huang, A.-C., Ji, B.-C., Lin, H.-Y., Chueh, F.-S., Yang, J.-S., Lu, C.-C., Ch, Chung, J.-G.* (2013) Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells. Environ., Toxicol. 28:579-587.,(SCI)
101Chang, Y.-T., Hsieh, C., Wu, L.-C., Chang, H.-C., Kao, S.-S., Meng, M.*, Hsieh, F.-C. * (2012) Purification and properties of an insecticidal metalloprotease produced by Photorhabdus luminescens strain 0805-P5G, the entomopathogenic nematode symbiont., Int. J. Mol. Sci. 14:308-321.,(SCI)
101Lin, H.-Y., Yu, C.-Y., Hsu, Y.-H., Meng, M*. (2012) Functional analysis of the conserved histidine residue of Bamboo mosaic virus capping enzyme in the activity for the formation of the covalent enzyme-m7GMP intermediate., FEBS Lett. 586:2326-2331,(SCI)
101Huang, Y.-W., Hu, C.-C., Liou, M.-R., Chang, B.-Y., Tsai, C.-H., Meng, M., Lin, N.-S., Hsu, Y.-H.* (2012) Hsp90 interacts specifically with viral RNA and differentially regulates replication initiation of Bamboo mosaic virus and associated satellite RNA., PLoS Pathog. May;8(5):e1002726,(SCI)
100Lee, C.-C., Ho, Y.-N., Hu, R.-H., Yen, Y.-T., Wang, Z.-C., Lee, Y.-C., Hsu, Y.-H., Meng, M.* (2011) The interaction between Bamboo mosaic virus replication protein and coat protein is critical for virus movement in plant hosts., J. Virol. 85:12022-12031.,(SCI)
100Prasanth, K. R., Huang, Y.-W., Liou, M.-R., Wang, R. Y.-L., Hu, C.-C., Tsai, C.-H., Meng, M., Lin, N, Hsu, Y.-H.* (2011) Glyceraldehyde 3-phosphate dehydrogenase negatively regulates the replication of Bamboo mosaic virus and its associated satellite RNA., J. Virol. 85:8829-8840.,(SCI)
100Liu, K.-C., Huang, A.-C., Wu, P.-P., Lin, H.-Y., Chueh, F.-S., Yang, J.-S., Lu, C.-C., Chiang, J.-H., Chung, J.-G.* (2011) Gallic acid suppresses the migration and invasion of PC-3human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways., Oncol. Rep. 26:177-184.,(SCI)
100Hu, R.-H., Lin, M.-C., Hsu, Y.-H., Meng. M.* (2011) Mutational effects of the consensus aromatic residues in the mRNA capping domain of Bamboo mosaic virus on GTP methylation and virus accumulation., Virology 411:15-24.,(SCI)
99Chen, I.-H., Lin, J.-W., Chen, Y.-J., Wang, Z.-C., Liang, L.-F., Meng, M., Hsu, Y.-H., Tsai, C.-H.* (2010) The 3′-terminal sequence of Bamboo mosaic virus minus-strand RNA interacts with RNA-dependent RNA polymerase and initiates plus-strand RNA synthesis., Mol. Plant Path. 11:203-212,(SCI)
98Cheng, Y.-M., Hsieh, F.-C., Meng, M.*. (2009) Functional analysis of conserved aromatic amino acids in the discoidin domain of Paenibacillus β-1,3-glucanase. Microb., Cell Factories 8:62,(SCI)
98Han, Y.-T., Hsu, Y.-H., Lo, C.-W., Meng, M.*. (2009) Identification and functional characterization of regions that can be crosslinked to RNA in the helicase-like domain of BaMV replicase., Virology 389:34-44.,(SCI)
98Cheng, C.-W., Hsiao, Y.-Y., Wu, H.-C., Chuang, C.-M., Chen, J.-S., Tsai, C.-H., Hsu, Y.-H., Wu, Y.-C, Meng, M.*. (2009) Suppression of Bamboo mosaic virus accumulation by a putative methyltransferase in Nicotiana benthamiana., J. Virol. 83:5796-5805.,(SCI)
98Sheu, J.-N., Chen, S.-M., Meng, M., Lue, K.-H. (2009) The Role of Serum and Urine Interleukin-8 on Acute Pyelonephritis and Subsequent Renal Scarring in Children., Pediatr. Infect. Dis. J. 28:885-890.,(SCI)
98Hsieh, F.-C.,Tzeng, C.-Y., Tseng, J.-T., Tsai, Y.-S., Meng, M.*, Kao, S.-S.* (2009) Isolation and characterization of the native entomopathogenic nematode, Heterorhabditis brevicaudis, and its symbiotic bacteria from Taiwan., Curr Microbiol. 58:564-570.,(SCI)
98Lin, H.-Y., Kao, Y.-H., Chen, S.-T., Meng, M.*. (2009) Effects of inherited mutations on catalytic activity and structural stability of human glucose-6-phosphate isomerase expressed in Escherichia coli., Biochim. Biophys. Acta. 1794:315-323,(SCI)
98Cheng , Y.-M., Hong, T.-Y., Liu, C.-C., Meng, M.*. (2009) Cloning and functional characterization of a complex endo-β-1,3-glucanase from Paenibacillus sp. Appl., Microbiol. Biotechnol. 81:1051-1061.,(SCI)
97Hong, T.-Y., Hsiao, Y.-Y., Meng, M., Li, T.-H, T*. (2008) The 1.5 Å structure of endo-1,3-β-glucanase from Streptomyces sioyaensis: evolution of the active-site structure for 1,3-β-glucan-binding specificity and hydrolysis., Acta Cryst. D64:964–970,(SCI)
97Hsieh, F.-C., Lin, T.-C., Meng, M.*, Kao, S.-S.* (2008) Comparing methods for identifying Bacillus strains capable of producing the antifungal lipopeptide iturin A., Curr Microbiol. 56:1-5.,(SCI)
96Han, Y.-T., Tsai, C.-S., Chen, Y.-C., Lin, M.-K., Hsu, Y.-H., Meng, M.*. (2007) Mutational analysis of a helicase motif-based RNA5’-triphosphatase/NTPase from bamboo mosaic virus., Virology 367:41-50.,(SCI)
94Huang, Y.-L., Hsu, Y.-H., Han, Y.-T., Meng, M.*.(2005) mRNA Guanylation Catalyzed by the S-Adenosylmethionine-dependent Guanylyltransferase of Bamboo Mosaic Virus., J. Biol. Chem. 280:13153-13162.,(SCI)
93Huang, Y.-L., Han, Y.-T., Chang, Y.-T., Hsu, Y.-H., Meng, M.* (2004). Critical residues for GTP methylation and formation of the covalent m7GMP-enzyme intermediate in the capping enzyme domain of Bamboo mosaic virus., J. Virol. 78:1271-1280. ,(SCI)
92Chen, I.-H., Meng, M., Hsu, Y.-H., Tsai, C.-H. (2003) Functional analysis of the cloverleaf-like structure in the 3’ untranslated region of Bamboo mosaic potexvirus RNA revealed dual roles in viral RNA replication and long distance movement., Virology 315:415-424.,(SCI)
92Hong, T.-Y., and Meng, M.* (2003) Biochemical characterization and antifungal activity of an endo-1,3-β-glucanase of Paenibacillus sp. isolated from garden soil. Appl. Microbiol., Biotechnol. 61:472-478.,(SCI)
91Hong, TY, Cheng, CW, Huang, JW, Meng, M.* (2002) Isolation and biochemical characterization of an endo-1,3-β-glucanase from Streptomyces sioyaensis containing a C-terminal family 6 carbohydrate-binding module that binds to 1,3-β-glucan., Microbiology (UK) 148:1151-1159.,(SCI)
90Li, Y.-I., Shih, T.-W., Hsu, Y.-H., Han Y.-T., Huang, Y.-L., & Meng, M.* (2001) The helicase-like domain of plant potexvirus replicase participates in the formation of 5’ cap structure of RNA by exhibiting an RNA 5’-triphosphatase activity., J. Virol. 75:12114-12120.,(SCI)
90Meng, M.*, Lin, H.-Y., Hsieh, C.-J., & Chen, Y.-T. (2001) Functions of the conserved anionic amino acids and those interacting with the substrate phosphate group of phosphoglucose isomerase., FEBS Lett. 499:11-14.,(SCI)
90Huang, C.-Y., Huang, Y.-L., Meng, M., Hsu, Y.-H., and Tsai, C.-H. (2001) Sequences at the 3’ untranslated region of the bamboo mosaic potexvirus RNA interact with the viral RNA-dependent RNA polymerase., J. Virol. 75:2818-2824. ,(SCI)
90Li, Y.-I., Chen, Y.-J., Hsu, Y.-H., & Meng, M.* (2001) Characterization of the AdoMet-dependent guanylyltransferase activity that is associated with the N-terminus of bamboo mosaic virus replicase., J. Virol. 75:782-788. ,(SCI)
89Chou, C.-C., Sun, Y.-J., Meng, M.*, & Hsiao, C.-D*.(2000) The crystal structure of phosphoglucose isomerase/ autocrine motility factor/ neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/ receptor recognition., J. Biol. Chem. 275:23154-23160.,(SCI)
88Meng, M.*, Chane, T.-L., Sun, Y. J., & Hsiao, C. D. (1999) Probing the location and function of the conserved histidine residue of phosphoglucose isomerase by using an active-site directed inhibitor N-bromoacetylethanolamine phosphate., Protein Science 8:2438-2443. ,(SCI)
88Sun, Y.-J., Chou, C.-C., Chen, W. S., Wu, R. T., Meng, M., & Hsiao, C. D.(1999) The crystal structure of a multifunctional protein: phosphoglucose isomerase/ autocrine motility factor/ neuroleukin., Proc. Natl. Acad. Sci. (USA) 96:5412-5417.,(SCI)
87Li, Y.-I., Cheng, Y.-M., Huang, Y.-L., Tsai, C.-H., Hsu, Y.-H., & Meng, M.* (1998) Identification and characterization of the E. coli-expressed RNA-dependent RNA polymerase of bamboo mosaic virus., J. Virol. 72:10093-10099. ,(SCI)
87Meng, M.*, Chen, Y.-T., Hsiao, Y.-Y., Itoh, Y., & Bagdasarian, M. (1998) Mutational analysis of the conserved cationic residues of Bacillus stearothermophilus 6-phosphoglucose isomerase. Europ., J. Biochem. 257:500-505. ,(SCI)
86Hsiao, C.-D., Chou, C.-C., Hsiao, Y.-Y., Sun, Y.-J., & Meng, M.* (1997) Expression, purification, and crystallization of two isozymes of 6-phosphoglucose isomerase of Bacillus stearothermophilus., J. Struct. Biol. 120:196-200. ,(SCI)
86Davie, J. R., Wynn, R. M., Meng, M., Huang, Y., Aalund, G., Chuang, D. T., & Lau, K. S. (1995) Expression and characterization of branched-chain α-keto acid dehydrogenase kinase from the rat. , J. Biol. Chem. 270:19861-19867.,(SCI)
79,Lee, C., Bagdasarian, M., Meng, M., & Zeikus, J. G. (1990) Catalytic mechanism of xylose (glucose) isomerase from Clostridium thermosulfurogenes, J. Biol. Chem., 265:19082-19090.,(SCI)
77,Hsieh, J.-H., Shih, K.-U., Kung, H.-F., Shiang, M., Lee, L.-Y., Meng, M., Chang, C.-C., Lin, H.-M., Shih, S.-H., Lee, S.-Y. (1988) Controlled fed-batch fermentation of recombinant Saccharomyces cerevisiae to produce hepatitis B surface antigen. Biotech. & Bioeng. 32:334-340.,(SCI)
77,Liu, W.-H., Meng, M., Chen, K.-S. (1988) Purification and some properties of cholesterol oxidases produced by an inducible and a constitutive mutant of Arthrobacter simplex. Agric. Biol. Chem. 52:413-418.
Diyapoglu, A., Oner, M., Meng, M*. ,(2022) Application potential of bacterial volatile organic compounds in the control of root-knot nematodes. ,Molecules 27, 4355.
Meng, M., Chuang, D. T. (1994) Site-directed mutagenesis and functional analysis of the active-site residues of the E2 component of bovine branched-chain alpha-keto acid dehydrogenase complex., Biochemistry 33: 12879-12885.,(SCI)
Meng, M., Bagdasdrian, M., & Zeikus, J. G. (1993) The role of active-site aromatic and polar residues in catalysis and substrate discrimination by xylose isomerase, Proc., Natl. Acad. Sci. USA, 90:8459-8463.,(SCI)
Meng, M., Bagdasarian, M., & Zeikus, J. G. (1993) Thermal stabilization of xylose isomerase from Thermoanaerobacterium thermosulfurigenes., Bio/technology, 11:1157-1161.
Meng, M., Lee, C., Bagdasarian, M., & Zeikus, J. G. (1991) Switching substrate preference of thermophilic xylose isomerase from D-xylose to D-glucose by redesigning the substrate binding pocket., Proc. Natl. Acad. Sci. USA, 88: 4015-4019.,(SCI)
Chen, B.-S., Chen, G.-C., Hsieh, J.-H., Meng, M., Tsai, T.-F., Liu, J.-J., Huang, J.-H., Chang, T.-H. (1990) Large-scale production of monoclonal antibodies using hollow fiber bioreactor., Chinese J. Microbiol. Immunol 23:75-88.,(SCI)
Meng, M., Chang, C.-C., Hsieh, J.-H., Feng, T.-Y., Kuo, T.-T. (1988) Fermentation studies of a recombinant Saccharomyces cerevisiae on the expression of the hepatitis B surface antigen using the yeast alcohol dehydrogenase I promoter., J. Chinese Agri. Chem. Soc. 26:302-310.
Meng, M., Chen, G.-C., Hsieh, J.-H., Yueh, Y., Chen, S.-C., Chang, T.-H., Tsao, D. (1988) Continuous production of anti-hepatitis B surface antigen monoclonal antibody in hollow fiber perfusion bioreactor. ,Chinese J. Microbiol. Immunol. 21:125-140.,(SCI)
123
年度活動名稱主題/發表題目活動單位活動期間
Biography2023-03-10~2023-03-10
年度獎項名稱頒獎單位
2004傑出研究獎國科會
終身榮譽特聘教授
學校名稱國別系所學位起迄年月
德克薩斯大學達拉斯西南醫學中心美國生物化學與分子生物學系博士後研究1993-03~1994-03
密西根州立大學美國微生物學系博士1988-09~1992-07
國立台灣大學台灣農業化學系碩士1983-09~1985-07
國立台灣大學台灣農業化學系學士1977-09~1981-07
服務機關名稱單位職務期間
中興大學生物科技學研究所所長2019-08~
中興大學生物科技學研究所所長2008-08~2014-08
中興大學生物科技學士學位學程主任2008-08~2014-08
中興大學研究發展處學術發展組組長2001-08~2004-08
中興大學生物科技學研究所教授2001-08~
中興大學生物科技學研究所副教授1994-08~2001-08
美國德州大學西南醫學中心(達拉斯)生化暨分子生物學系博士後研究1993-08~1994-08