- 國立中興大學生物科技學研究所

基本資料表

姓名

曾志正←

聯絡電話

(04)22840328 ext. 776, 777,

TCTZEN@dragon.nchu.edu.tw

Fax

04-22853527

教師

類別

專任師資

職稱

教授

授課領域

•上學期：
種子油體
油體蛋白特論
中草藥分子機制
生物化學特論

•下學期：
種子油體
油體蛋白特論
中草藥分子機制
生物技術特論

研究專長

人造油體技術開發、飲茶之科學研究、中草藥有效成分之功效分子機制研究

個人網址

https://tzentea.weebly.com

實驗室微電影

https://www.youtube.com/watch?v=RuasXuJNX6M&t=12s

學年度	論文名稱
109	Hsieh SK, Lin HY, Chen CJ, Jhuo CF, Liao KY, Chen WY, Tzen JTC.,Promotion of myotube differentiation and attenuation of muscle atrophy in murine C2C12 myoblast cells treated with teaghrelin,Chemico-Biological Interactions,315,(SCI)
109	,Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet,MOLECULES,(SCI)
108	Yue‐Chiun Li, Chieh‐Ju Wu, Yi‐Chiao Lin, Ruo‐Hsuan W,u Wen‐Ying Chen, Ping‐Chung Kuo, Jason T. C,Identification of two teaghrelins in Shy‐jih‐chuen oolong tea, Journal of Food Biochemistry , 43, pp11,(SCI)
108	Chieh-Ju Wu, Mei-Yin Chien, Nan-Hei Lin, Yi-Chiao Lin, Wen-Ying Chen, Chao-Hsiang Chen,and Jason T. ,Echinacoside Isolated from Cistanche tubulosa Putatively Stimulates Growth Hormone Secretion via Activation of the Ghrelin Receptor,Molecules,24,(SCI)
108	Yue-Chiun Li, Ping-Chung Kuo*, Mei-Lin Yang, Tzu-Yu Chen, Tsong-Long Hwang, Chih-Chao Chiang, Tran D,Chemical Constituents of the Leaves of Peltophorum pterocarpum and Their Bioactivity,Molecules,24,(SCI)
108	Yu-En Shih ,Chao-Hsiang Chen ,Nan-Hei Lin and Jason T.C. Tzen,Development of Indirect Competitive ELISA for Lithospermic Acid B of Salvia miltiorrhiza with Its Specific Antibodies Generated via Artificial Oil Bodies,Molecules,24,(SCI)
108	Sio-Hong Lam, Yue-Chiun Li, Ping-Chung Kuo * , Tsong-Long Hwang , Mei-Lin Yang, Chien-Chiao Wangand,Chemical constituents of Vigna luteola and their anti-inflammatory bioactivity,24,(SCI)
108	Yu-En Shih, Chao-Hsiang Chen, Nan-Hei Linand Jason T.C. Tzen,Development of Indirect Competitive ELISA for Lithospermic Acid B of Salvia miltiorrhiza with Its Specific Antibodies Generated via Artificial Oil Bodies,Molecules,24,(SCI)
108	Ping-Chung Kuo, Yue-Chiun Li, Ruo-Hsuan Wu and Jason T. C. Tzen, Characterization of teaghrelin-like compounds from tea cultivars,NATURAL PRODUCT RESEARCH,(SCI)
107	Chi-Hui Sun, Chin-Ying Yang* and Jason T. C. Tzen*,Molecular Identification and Characterization of Hydroxycinnamoyl Transferase in Tea Plants (Camellia sinensis L.),International Journal of Molecular Sciences,19,(SCI)
107	Tzu-Yin Chena , Miki M.C. Wanga,Sheng-Kuo Hsieha, Meng-Huang Hsiehb, Wen-Ying Chenc* and Jason T.C. ,Pancreatic lipase inhibition of strictinin isolated from Pu'er tea (Cammelia sinensis) and its anti-obesity effects in C57BL6 mice,Journal of Functional Foods,48, pp1-8,(SCI)
107	,Ke SW, Chen GH, Chen CT, Tzen JTC, Yang CY (2018) Ethylene signaling modulates contents of catechin and ability of antioxidant in Camellia sinensis. Bot Stud 59: 11,(SCI)
107	,Richart SM, Li YL, Mizushina Y, Chang YY, Chung TY, Chen GH, Tzen JTC, Shia KS, Hsu WL (2018) Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection. J Food Drug Anal 26: 1015-1023,(SCI)
107	,Wang MMC, Yeh Y, Shih YE, Tzen JTC* (2018) Relative content of gallic acid over 5-galloylquinic acid as an index for the baking intensity of oolong teas. J Food Drug Anal 26: 609-619,(SCI)
107	,Chung TY, Lin NH, Li YC, Chen TY, Kuo PC, Chen WY, Tzen JTC (2018) Detection of lithospermate B in rat plasma at the nanogram level by LC/MS in multi reaction monitoring mode. J Food Drug Anal 26: 353-361 ,(SCI)
107	,Liao ZH, Chen YJ, Tzen JTC, Kuo PC, Lee MR, Mai FD, Rairat T, Chou CC (2018) Effect of teapot materials on the chemical composition of oolong tea infusions. J Sci Food Agric 98: 751-757,(SCI)
107	,Chen GH, Li YC, Lin NH, Kuo PC, Tzen JTC (2018) Characterization of Vasorelaxant Principles from the Needles of Pinus morrisonicola Hayata. Molecules 23: 86.,(SCI)
106	,Lin IS, Wu YS, Chen CT, Chen GH, Hwang SG, Jauh GY, Tzen JTC, Yang CY (2017) AtRBOH I confers submergence tolerance and is involved in auxin-mediated signaling pathways under hypoxic stress. Plant Growth Regul 83: 277-285,(SCI)
106	,Lai GH, Lien YY, Lin MK, Cheng JH, Tzen JTC, Sun FC, Lee MS, Chen HJ, Lee MS (2017) VP2 of Chicken Anaemia Virus Interacts with Apoptin for Down-regulation of Apoptosis through De-phosphorylated Threonine 108 on Apoptin. Sci Rep. 7: 14799,(SCI)
106	,Shih YE, Lin YC, Chung TY, Liu MC, Chen GH, Wu CC, Tzen JTC* (2017) In vitro assay to estimate tea astringency via observing flotation of artificial oil bodies sheltered by caleosin fused with histatin 3. J Food Drug Anal 25: 828-836 ,(SCI)
106	,Lin CH, Lee MC, Tzen JTC, Lee HM, Chang SM, Tu WC, Lin CF (2017) Efficacy of Mastoparan-AF alone and in combination with clinically used antibiotics on nosocomial multidrug-resistant Acinetobacter baumannii. Saudi J Biol Sci 24: 1023-1029.,(SCI)
106	,Pasaribu B, Chen CS, Liao YK, Jiang PL, Tzen JTC (2017) Identification of caleosin and oleosin in oil bodies of pine pollen. Plant Physiol Biochem 111: 20-29,(SCI)
105	,Hsieh SK, Chung TY, Li YC, Lo YH, Lin NH, Kuo PC, Chen WY, Tzen JTC* (2016) Ginkgoghrelins, unique acylated flavonoid diglycosides in Folium Ginkgo, stimulate growth hormone secretion via activation of the ghrelin receptor. J Ethnopharmacol 193: 237-247,(SCI)
105	,Lin YC, Tsai LC, Lee JC, Su CW, Tzen JTC, Linacre A, Hsieh HM (2016) Novel identification of biofluids using a multiplex methylation sensitive restriction enzyme-PCR system. Forensic Sci Int Genet. 25: 157-165,(SCI)
105	,Hsieh SK, Xu JR, Lin NH, Lo YH, Li YC, Chen GH, Kuo PC, Chen WY, Tzen JTC* (2016) Antibacterial and laxative activities of strictinin isolated from Pu’er tea (Cammelia sinensis). J Food Drug Anal 24: 722-729,(SCI)
105	,Chien HJ, Chu YW, Chen CW, Juang YM, Chien MW, Liu CW, Wu CC, Tzen JTC, Lai CC (2016) 2-DE combined with two-layer feature selection accurately establishes the origin of oolong tea. Food Chem. 211:392-399,(SCI)
105	,Tang HJ, Ruan LJ, Tian HY, Liang GP, Ye WC, Hughes E, Esmann M, Fedosova NU, Chung TY, Tzen JTC, Jiang RW, Middleton DA (2016) Novel stereoselective bufadienolides reveal new insights into the requirements for Na(+), K(+)-ATPase inhibition by cardiotonic steroids. Sci Rep. 6: 29155,(SCI)
105	,Lin YC, Tsai LC, Lee JC, Liu KL, Tzen JTC, Linacre A, Hsieh HM (2016) Novel identification of biofluids using a multiplex methylation-specific PCR combined with single-base extension system. Forensic Sci Med Pathol. 12: 128-138,(SCI)
105	,Pasaribu B, Li YS, Kuo PC. Lin IP, Tew, KS, Tzen JTC, Liao YK, Chen CS, Jiang PL* (2016) The effect of temperature and nitrogen deprivation on cell morphology and physiology of Symbiodinium. Oceanologia 4: 272-278 ,(SCI)
105	,Pasaribu B, Chung TY, Chen CS, Jiang PL, Tzen JTC (2016) Identification of steroleosin in oil bodies of pine megagametophytes. Plant Physiol Biochem 101: 173-181,(SCI)
105	,hiu CH, Chen GH, Tzen JTC, Yang CY (2016) Molecular identification and characterization of a serine carboxypeptidase-like gene associated with abiotic stress in tea plant, Camellia sinensis (L.) Plant Growth Regul 79: 345-353,(SCI)
105	,Pasaribu B, Weng LC, Lin IP, Camargo E, Tzen JTC, Tsai CH, Ho SL, Lin MR, Wang LH, Chen CS, Jiang PL (2015) Morphological Variability and Distinct Protein Profiles of Cultured and Endosymbiotic Symbiodinium cells Isolated from Exaiptasia pulchella. Sci Rep 5: 15353,(SCI)
104	,Hsieh SK, Lo YH, Chung TY, Tzen JTC (2015) Identification of biosynthetic intermediates of teaghrelins and teaghrelin-like compounds in oolong teas, and their molecular docking to the ghrelin receptor. J Food Drug Anal 23: 660-670,(SCI)
104	,Chen YI, Tzeng CY, Cheng YW, Hsu TH, Ho WJ, Liang ZC, Hsieh CW, Tzen JTC, Chang SL (2015) The involvement of serotonin in the hypoglycemic effects produced by administration of the aqueous extract of Xylaria nigripes with steroid-induced insulin-resistant rats. Phytother Res 29: 770-776,(SCI)
104	,Cameron RG, Kim Y, Galant AL, Luzio GA, Tzen JTC (2015) Pectin homogalacturonans: Nanostructural characterization of methylesterified domains. Food Hydrocolloids 4:184-190,(SCI)
104	,Chen YJ, Lo YH, Chen YT, Lai NW, Lin NH, Chung TY, Chen WY, Tzen JTC (2015) Magnesium lithospermate B improves metabolic changes in high-fat diet-fed rats with metabolic syndrome. J Funct Food 14: 163-173,(SCI)
104	,Lo YH, Chen YJ, Chung TY, Lin NH, Chen WY, Chen CY, Lee MR, Chou CC, Tzen JTC* (2015) Emoghrelin, a unique emodin derivative in Heshouwu, stimulates growth hormone secretion via activation of the ghrelin receptor. J Ethnopharmacol 159: 1-8,(SCI)
104	,Chen GH, Lin YL, Hsu WL, Hsieh SK, Tzen JTC* (2015) Significant elevation of antiviral activity of strictinin from Pu’er tea after thermal degradation to ellagic acid and gallic acid. J Food Drug Anal 23: 116-123 ,(SCI)
104	,Chung TY, Kuo PC, Liao ZH, Shih YE, Yang ML, Cheng ML, Wu CC, Tzen JTC* (2015) Analysis of lipophilic compounds of tea coated on the surface of clay teapots. J Food Drug Anal 23: 71-81,(SCI)
103	,Zhang RR, Tian HY, Tan YF, Chung TY, Sun XH, Xia X, Ye WC, Middleton DA, Fedosova N, Esmann M, Tzen JTC, Jiang RW* (2014) Structures, chemotaxonomic significance, cytotoxic and Na+,K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica. Org Biomol Chem 12: 8919-8929,(SCI)
103	,Tseng CW, Liao CY, Sun Y, Peng CC, Tzen JTC, Guo RT, Liu JR (2014) Immobilization of Clostridium cellulolyticum d-Psicose 3-Epimerase on Artificial Oil Bodies. J Agric Food Chem 62: 6771-6776,(SCI)
103	, Pasaribu B, Chung TY, Chen CS, Wang SL, Jiang PL, Tzen JTC (2014) Identification of caleosin and two oleosin isoforms in oil bodies of pine megagametophytes. Plant Physiol Biochem 82: 142-150,(SCI)
103	,Lo YH, Chen YJ, Chang CI, Chen YW, Chen CY, Lee MR, Lee VSY, Tzen JTC* (2014) Teaghrelins, unique acylated flavonoid tetraglycosides in Chin-Shin oolong tea, are putative oral agonists of the ghrelin receptor. J Agric Food Chem 62: 5085-5091,(SCI)
103	,Pasaribu B, Lin IP, Tzen JTC, Jauh GY, Fan TY, Ju YM, Cheng JO, Chen CS, Jiang PL (2014) SLDP: a novel protein related to caleosin is associated with the endosymbiotic symbiodinium lipid droplets from Euphyllia glabrescens. Mar Biotechnol (NY) 16: 560-571,(SCI)
103	,Chen YJ, Chung TY, Chen WY, Chen CY, Lee MR, Jinn TR, Tzen JTC* (2014) Detecting metabolites of transition metal-lithospermate B complexes after intravenous injection in rats. Acta Pharmacol Sin 35: 937–944 ,(SCI)
103	,Lai GH, Lin YC, Tsai YL, Lien YY, Lin MK, Chen HJ, Chang WT, Tzen JTC, Lee MS (2014) High yield production of pigeon circovirus capsid protein in the E. coli by evaluating the key parameters needed for protein expression. BMC Vet Res 10:115.,(SCI)
103	,Chen GH, Yang CY, Lee SJ, Wu CC, Tzen JTC* (2014) Catechin content and the degree of its galloylation in oolong tea were inversely correlated with cultivation altitude. J Food Drug Anal 22: 303-309,(SCI)
103	,im Y, Williams MAK, Tzen JTC, Luzio GA, Galant AL, Cameron RG (2014) Characterization of charged functional domains introduced into a modified pectic homogalacturonan by an acidic plant pectin methylesterase (Ficus awkeotsang Makino) and modeling of enzyme mode of action. Food Hydrocolloids 39: 319-329,(SCI)
103	,Cheng ML, Tzen JTC, Shyu DJH, Chou WM (2014) Functional characterization of the N-terminal and C-terminal domains of a sesame group II phytocystatin. Botanical Studies 55: 18,(SCI)
103	,Chen DH, Jiang PL, Jinn TR, Tzen JTC (2014) Analysis of major constituents in seed cells of Aquilaria sinensis. J Food Nutr Res 2(1): 34-39,(SCI)
103	Ying-I Chen, Yu-Wen Cheng, Chung-Yuh Tzeng, Yu-Chen Lee, Yaw-Nan Chang, Shih-Chieh Lee, Chin-Chun Ts,Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats,BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,14,(SCI)

學年度	計畫名稱	參與人	計畫期間	補助/委託或合作機構
105	分析台灣不同鳳梨種植環境對於其中鳳梨酵素含量影響之試驗計畫		2021-11~2021-11	私人公司
107	台灣茶製程技術產學聯盟- II(1/3)		~	科技部
107	小型企業創新研發計畫(SBIR)		~	私人公司
107	人造油體技術應用於檢驗茶湯與紅酒之相對澀度		~	科技部
106	鈺統食品產品開發		~	私人公司
106	以人造油體技術平台生產丹參酚酸B與迷迭香酸抗體及發展脂質體包埋技術		~	科技部
106	"泰國籍 SaKon Monggoot亞太經濟合作(APEC)獎學金 "		~	教育部
106	台灣茶製程技術產學聯盟(3/3)-會員會費、技術服務收入		~	私人公司
106	台灣茶製程技術產學聯盟(3/3)		~	科技部
105	以人造油體技術平台生產丹參酚酸B與迷迭香酸抗體及發展脂質體包埋技術		~	科技部
105	台灣茶製程技術產學聯盟(2/3)		~	科技部
107	台灣茶製程技術產學聯盟		~	私人公司
105	台灣茶製程技術產學聯盟(2/3)-會員年費、技術服務費		~	私人公司
104	台灣茶製程技術產學聯盟(1/3)-會員年費		~	私人公司
104	台灣茶製程技術產學聯盟(1/3)		~	科技部
104	台灣二葉松及台灣五葉松松針萃取液及其發酵液中成份鑑定及活性之開發		~	私人公司
104	以人造油體技術平台生產丹參酚酸B與迷迭香酸抗體及發展脂質體包埋技術		~	科技部
104	台灣茶製程技術產學聯盟(1/3)-技術服務費		~	私人公司
103	包埋迷迭香酸及丹參酚酸B以提高生物可利用率研究		~	私人公司
103	研發電焙技術製備烏龍老茶之試驗		~	私人公司
103	以人造油體技術平台生產丹參酚酸B抗體及發展脂質體包埋藥性分子		~	科技部
103	分析白何首烏生長年份與氣味成份差異之計畫		~	私人公司

年度	專利類別	專利名稱	發表日期	專利人
2019	(專利)	銀杏飢素做為飢餓素受體促效劑之應用	2019-02	兆豐達生技有限公司
2017	(專利)	新穎之丹參酚酸Ｂ過渡金屬離子錯合物，其製法及於治療充血性心衰竭疾病的應用	2017-05	黃碧真
2017	(專利)	木麻黃素用於製備促進腸胃蠕動之組合物的用途	2017-11	兆豐達生技有限公司
2016	(專利)	包含富組蛋白３（Ｈｉｓｔａｔｉｎ３）之人造油體及其於檢測食品澀度之應用	2016-01	中興大學
2016	(專利)	一種快速純化木麻黃素之方法	2016-07	虎尾科技大學
2016	(專利)	青心烏龍茶萃取化合物及其做為飢餓素受體促效劑之應用	2016-11	中興大學
2016	(專利)	生何首烏萃取化合物做為飢餓素受體促效劑之應用	2016-11	臻旺生物科技股份有限公司
2015	(專利)	經改造之油體鈣蛋白（ｃａｌｅｏｓｉｎｓ）及其用於半抗原之抗體製造	2015-06	中興大學
2015	(專利)	難溶性薑黃素之人造油體遞送系統及其用於製備粉末及錠劑之用途	2015-06	中興大學
2015	(專利)	油體蛋白（ｏｌｅｏｓｉｎ）及修飾型態用於製備安定之新型微脂粒	2015-10	中興大學
2014	(專利)	楊梅黃酮與沒食子酸之天然甘味劑組合物	2014-06	中興大學
2014	(專利)	人造油體及其製造方法	2014-11	嘉南藥理大學
2014	(專利)	固化之油體，其製法及其於粉末與錠劑劑型之應用	2014-11	中興大學
2012	(專利)	基於油體之蛋白質固定	2012-04	中興大學
2012	(專利)	油体担体、標的療法及び／又は検出におけるその使用	2012-02	中國醫大
2012		油體載體及其於標靶治療及／或偵測之應用與其所包含之融合蛋白質	2012-12	中國醫大
2012		去氫羥化腎上腺皮質素用於增加內源性維生素Ｂ６濃度之用途	2012-12	中興大學
2010	(專利)	以轉殖植物生產高甲硫胺酸蛋白之方法及其所製得之產品	2010-01	中興大學
2010	(專利)	於穀類植物榖粒外皮表現外源蛋白質之方法	2010-10	中興大學
2010	(專利)	以油體為主之蛋白酶抑制劑的純化方法	2010-10	中興大學
2009	(專利)	基於油體之蛋白純化方法	2009-11	中興大學
2009	(專利)	一種利用植物油體為菌種載體之生物晶球及其方法	2009-07	侯建維
2008	(專利)	以油體鈣蛋白構築之重組人造油體	2008-07	中興大學
2008	(專利)	人造油體抗原展現系統	2008-10	中興大學
2007	(專利)	芝麻素及芝麻醇素用於預防中風及保護神經退化之用途	2007-03	中興大學台中榮總
2006	(專利)	經交聯劑處理過之穩定度提昇的油體	2006-03	嘉年生化公司

年度	活動名稱	主題/發表題目	活動單位	活動期間
2019	興大開啟台灣四季春烏龍茶產業升級	四季春含「茶飢素」發表於 Journal of Food Biochemistry	茶製程技術產學聯盟	2019-04-24~2019-04-24

學校名稱	國別	系所	學位	起迄年月
奧克拉荷馬州州立大學	美國	生化及分子生物所	博士後研究	1993-09~1994-09
加州大學河濱分校	美國		遺傳學博士	1989-09~1993-09
清華大學	中華民國	化學系	學士	1982-09~1986-09

服務機關名稱	單位	職務	期間
中興大學	生物科技學研究所	教授	1999-09~
中興大學	生物科技學研究所	副教授	1994-09~1999-09